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A Protecting‐Group‐Free Synthesis of (−)‐Salvinorin A

A concise enantioselective total synthesis of the neoclerodane diterpene (−)‐salvinorin A is reported. The stereogenic center at C‐12 was installed by catalytic asymmetric propargylation with excellent enantioselectivity, and the remaining six stereogenic centers were set up highly diastereoselectiv...

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Détails bibliographiques
Publié dans:Chemistry
Auteurs principaux: Zimdars, Patrick, Wang, Yuzhou, Metz, Peter
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252117/
https://ncbi.nlm.nih.gov/pubmed/33784436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202100560
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