Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species

BACKGROUND AND AIMS: Antifibrotic therapy remains an unmet medical need in human chronic liver disease. We report the antifibrotic properties of cytoglobin (CYGB), a respiratory protein expressed in hepatic stellate cells (HSCs), the main cell type involved in liver fibrosis. APPROACH AND RESULTS: C...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Hepatology
Päätekijät: Dat, Ninh Quoc, Thuy, Le Thi Thanh, Hieu, Vu Ngoc, Hai, Hoang, Hoang, Dinh Viet, Thi Thanh Hai, Nguyen, Thuy, Tuong Thi Van, Komiya, Tohru, Rombouts, Krista, Dong, Minh Phuong, Hanh, Ngo Vinh, Hoang, Truong Huu, Sato‐Matsubara, Misako, Daikoku, Atsuko, Kadono, Chiho, Oikawa, Daisuke, Yoshizato, Katsutoshi, Tokunaga, Fuminori, Pinzani, Massimo, Kawada, Norifumi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2021
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251927/
https://ncbi.nlm.nih.gov/pubmed/33576020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31752
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