Single‐Molecule Counting Coupled to Rapid Amplification Enables Detection of α‐Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients

α‐Synuclein aggregation is a hallmark of Parkinson's disease and a promising biomarker for early detection and assessment of disease progression. The prospect of a molecular test for Parkinson's disease is materializing with the recent developments of detection methods based on amplificati...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Bhumkar, Akshay, Magnan, Chloe, Lau, Derrick, Jun, Eugene Soh Wei, Dzamko, Nicolas, Gambin, Yann, Sierecki, Emma
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251908/
https://ncbi.nlm.nih.gov/pubmed/33511725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202014898
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