A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice

Optimal vaccines are needed for sustained suppression of SARS‐CoV‐2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene for the SARS‐CoV‐2 S1 subunit antigen (Ad5.SARS‐CoV‐2‐S1) for COVID‐19 immunization and evaluated its immunogenicity in mice....

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Dades bibliogràfiques
Publicat a:Eur J Immunol
Autors principals: Kim, Eun, Weisel, Florian J., Balmert, Stephen C., Khan, Muhammad S., Huang, Shaohua, Erdos, Geza, Kenniston, Thomas W., Carey, Cara Donahue, Joachim, Stephen M., Conter, Laura J., Weisel, Nadine M., Okba, Nisreen M. A., Haagmans, Bart L., Percivalle, Elena, Cassaniti, Irene, Baldanti, Fausto, Korkmaz, Emrullah, Shlomchik, Mark J., Falo, Louis D., Gambotto, Andrea
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Immunity to infection
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8250272/
https://ncbi.nlm.nih.gov/pubmed/33772778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.202149167
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