A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice

Optimal vaccines are needed for sustained suppression of SARS‐CoV‐2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene for the SARS‐CoV‐2 S1 subunit antigen (Ad5.SARS‐CoV‐2‐S1) for COVID‐19 immunization and evaluated its immunogenicity in mice....

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Kim, Eun, Weisel, Florian J., Balmert, Stephen C., Khan, Muhammad S., Huang, Shaohua, Erdos, Geza, Kenniston, Thomas W., Carey, Cara Donahue, Joachim, Stephen M., Conter, Laura J., Weisel, Nadine M., Okba, Nisreen M. A., Haagmans, Bart L., Percivalle, Elena, Cassaniti, Irene, Baldanti, Fausto, Korkmaz, Emrullah, Shlomchik, Mark J., Falo, Louis D., Gambotto, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Immunity to infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8250272/
https://ncbi.nlm.nih.gov/pubmed/33772778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.202149167
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