A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced MLL Rearrangements

Rearrangements in the Mixed Lineage Leukemia breakpoint cluster region (MLLbcr) are frequently involved in therapy-induced leukemia, a severe side effect of anti-cancer therapies. Previous work unraveled Endonuclease G as the critical nuclease causing initial breakage in the MLLbcr in response to di...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Eberle, Julia, Wiehe, Rahel Stefanie, Gole, Boris, Mattis, Liska Jule, Palmer, Anja, Ständker, Ludger, Forssmann, Wolf-Georg, Münch, Jan, Gebhardt, J. Christof M., Wiesmüller, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249925/
https://ncbi.nlm.nih.gov/pubmed/34222016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.689063
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