COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge

Vaccine-associated enhanced respiratory disease (VAERD) was previously observed in some preclinical models of severe acute respiratory syndrome (SARS) and MERS coronavirus vaccines. We used the SARS coronavirus 2 (SARS-CoV-2) mouse-adapted, passage 10, lethal challenge virus (MA10) mouse model of ac...

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保存先:
書誌詳細
出版年:Immunity
主要な著者: DiPiazza, Anthony T., Leist, Sarah R., Abiona, Olubukola M., Moliva, Juan I., Werner, Anne, Minai, Mahnaz, Nagata, Bianca M., Bock, Kevin W., Phung, Emily, Schäfer, Alexandra, Dinnon, Kenneth H., Chang, Lauren A., Loomis, Rebecca J., Boyoglu-Barnum, Seyhan, Alvarado, Gabriela S., Sullivan, Nancy J., Edwards, Darin K., Morabito, Kaitlyn M., Mascola, John R., Carfi, Andrea, Corbett, Kizzmekia S., Moore, Ian N., Baric, Ralph S., Graham, Barney S., Ruckwardt, Tracy J.
フォーマット: Artigo
言語:Inglês
出版事項: Cell Press 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249710/
https://ncbi.nlm.nih.gov/pubmed/34270939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2021.06.018
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