The noncanonical role of the protease cathepsin D as a cofilin phosphatase

Cathepsin D (cathD) is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments. Here we report cathD plays an unconventional role as a cofilin phosphatase orchestrating actin remodeling. In neutral pH environments, the cathD precursor directly dephosphorylates...

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Udgivet i:Cell Res
Main Authors: Liu, Yi-Jun, Zhang, Ting, Chen, Sicong, Cheng, Daxiao, Wu, Cunjin, Wang, Xingyue, Duan, Duo, Zhu, Liya, Lou, Huifang, Gong, Zhefeng, Wang, Xiao-Dong, Ho, Margaret S., Duan, Shumin
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8249557/
https://ncbi.nlm.nih.gov/pubmed/33514914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-00454-w
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