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Novel ORAI1 Mutation Disrupts Channel Trafficking Resulting in Combined Immunodeficiency
Store-operated Ca(2+) entry (SOCE) represents a predominant Ca(2+) influx pathway in non-excitable cells. SOCE is required for immune cell activation and is mediated by the plasma membrane (PM) channel ORAI1 and the endoplasmic reticulum (ER) Ca(2+) sensor STIM1. Mutations in the Orai1 or STIM1 gene...
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| Publicado no: | J Clin Immunol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8249264/ https://ncbi.nlm.nih.gov/pubmed/33650027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-021-01004-8 |
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