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The CCT chaperonin is a novel regulator of Ca(2+) signaling through modulation of Orai1 trafficking
Store-operated Ca(2+) entry (SOCE) encodes a range of cellular responses downstream of Ca(2+) influx through the SOCE channel Orai1. Orai1 recycles at the plasma membrane (PM), with ~40% of the total Orai1 pool residing at the PM at steady state. The mechanisms regulating Orai1 recycling remain poor...
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| Veröffentlicht in: | Sci Adv |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Association for the Advancement of Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6157965/ https://ncbi.nlm.nih.gov/pubmed/30263962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau1935 |
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