A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

ER proteins of widely differing abundance are retrieved from the Golgi by the KDEL-receptor. Abundant ER proteins tend to have KDEL rather than HDEL signals, whereas ADEL and DDEL are not used in most organisms. Here, we explore the mechanism of selective retrieval signal capture by the KDEL-recepto...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gerondopoulos, Andreas, Bräuer, Philipp, Sobajima, Tomoaki, Wu, Zhiyi, Parker, Joanne L, Biggin, Philip C, Barr, Francis A, Newstead, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248988/
https://ncbi.nlm.nih.gov/pubmed/34137369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68380
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