A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

ER proteins of widely differing abundance are retrieved from the Golgi by the KDEL-receptor. Abundant ER proteins tend to have KDEL rather than HDEL signals, whereas ADEL and DDEL are not used in most organisms. Here, we explore the mechanism of selective retrieval signal capture by the KDEL-recepto...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Gerondopoulos, Andreas, Bräuer, Philipp, Sobajima, Tomoaki, Wu, Zhiyi, Parker, Joanne L, Biggin, Philip C, Barr, Francis A, Newstead, Simon
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2021
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248988/
https://ncbi.nlm.nih.gov/pubmed/34137369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68380
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