MRI‐assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction

INTRODUCTION: The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep–wake cycle, modulating cognitive function, and AD progression. METHODS: Participants were 481 men (ages 62 to 71.7) from the Vietnam Era T...

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Pubblicato in:Alzheimers Dement
Autori principali: Elman, Jeremy A., Puckett, Olivia K., Beck, Asad, Fennema‐Notestine, Christine, Cross, Latonya K., Dale, Anders M., Eglit, Graham M. L., Eyler, Lisa T., Gillespie, Nathan A., Granholm, Eric L., Gustavson, Daniel E., Hagler, Donald J., Hatton, Sean N., Hauger, Richard, Jak, Amy J., Logue, Mark W., McEvoy, Linda K., McKenzie, Ruth E., Neale, Michael C., Panizzon, Matthew S., Reynolds, Chandra A., Sanderson‐Cimino, Mark, Toomey, Rosemary, Tu, Xin M., Whitsel, Nathan, Williams, McKenna E., Xian, Hong, Lyons, Michael J., Franz, Carol E., Kremen, William S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248066/
https://ncbi.nlm.nih.gov/pubmed/33580733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12261
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