Targeting the m(6)A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication

N(6)-methyladenosine (m(6)A) is an abundant internal RNA modification, influencing transcript fate and function in uninfected and virus-infected cells. Installation of m(6)A by the nuclear RNA methyltransferase METTL3 occurs cotranscriptionally; however, the genomes of some cytoplasmic RNA viruses a...

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Vydáno v:Genes Dev
Hlavní autoři: Burgess, Hannah M., Depledge, Daniel P., Thompson, Letitia, Srinivas, Kalanghad Puthankalam, Grande, Rebecca C., Vink, Elizabeth I., Abebe, Jonathan S., Blackaby, Wesley P., Hendrick, Alan, Albertella, Mark R., Kouzarides, Tony, Stapleford, Kenneth A., Wilson, Angus C., Mohr, Ian
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247602/
https://ncbi.nlm.nih.gov/pubmed/34168039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.348320.121
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