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Mitochondrial DNA copy number in human disease: the more the better?

Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that is essential for oxidative phosphorylation (OXPHOS). In mammals, a gene‐dense circular mitochondrial DNA (mtDNA) of about 1...

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Foilsithe in:FEBS Lett
Main Authors: Filograna, Roberta, Mennuni, Mara, Alsina, David, Larsson, Nils‐Göran
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8247411/
https://ncbi.nlm.nih.gov/pubmed/33314045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.14021
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