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Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine
AIMS: Carbamazepine can cause hypersensitivity reactions in ~10% of patients. An immunogenic effect can be produced by the electrophilic 10,11‐epoxide metabolite but not by carbamazepine. Hypothetically, certain single nucleotide polymorphisms might increase the formation of immunogenic metabolites,...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8247401/ https://ncbi.nlm.nih.gov/pubmed/33217013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14667 |
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