Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT

BACKGROUND: Metastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein apurinic/apyrimidinic endonuclease 1 (APE1) promotes tumor metastasis and is overexpressed in cervical cancer. However, the biological role and mechanism of APE1 in...

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Dades bibliogràfiques
Publicat a:J Exp Clin Cancer Res
Autors principals: Li, Qing, Zhou, Zhi-Wei, Duan, Wei, Qian, Cheng-Yuan, Wang, Shu-Nan, Deng, Meng-Sheng, Zi, Dan, Wang, Jian-Min, Mao, Cheng-Yi, Song, Guanbin, Wang, Dong, Westover, Kenneth D., Xu, Cheng-Xiong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246661/
https://ncbi.nlm.nih.gov/pubmed/34210327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-02006-5
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