Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage

BACKGROUND: The evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte structural and functional proteins, influencing responses to hemolytic stress during transfusion and disease. METHODS: We sought to identify such genetic varia...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Page, Grier P., Kanias, Tamir, Guo, Yuelong J., Lanteri, Marion C., Zhang, Xu, Mast, Alan E., Cable, Ritchard G., Spencer, Bryan R., Kiss, Joseph E., Fang, Fang, Endres-Dighe, Stacy M., Brambilla, Donald, Nouraie, Mehdi, Gordeuk, Victor R., Kleinman, Steve, Busch, Michael P., Gladwin, Mark T.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2021
Sujets:
Clinical Medicine
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245173/
https://ncbi.nlm.nih.gov/pubmed/34014839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146077
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