Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage

BACKGROUND: The evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte structural and functional proteins, influencing responses to hemolytic stress during transfusion and disease. METHODS: We sought to identify such genetic varia...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Page, Grier P., Kanias, Tamir, Guo, Yuelong J., Lanteri, Marion C., Zhang, Xu, Mast, Alan E., Cable, Ritchard G., Spencer, Bryan R., Kiss, Joseph E., Fang, Fang, Endres-Dighe, Stacy M., Brambilla, Donald, Nouraie, Mehdi, Gordeuk, Victor R., Kleinman, Steve, Busch, Michael P., Gladwin, Mark T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Clinical Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245173/
https://ncbi.nlm.nih.gov/pubmed/34014839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146077
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