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Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage

BACKGROUND: The evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte structural and functional proteins, influencing responses to hemolytic stress during transfusion and disease. METHODS: We sought to identify such genetic varia...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Page, Grier P., Kanias, Tamir, Guo, Yuelong J., Lanteri, Marion C., Zhang, Xu, Mast, Alan E., Cable, Ritchard G., Spencer, Bryan R., Kiss, Joseph E., Fang, Fang, Endres-Dighe, Stacy M., Brambilla, Donald, Nouraie, Mehdi, Gordeuk, Victor R., Kleinman, Steve, Busch, Michael P., Gladwin, Mark T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245173/
https://ncbi.nlm.nih.gov/pubmed/34014839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146077
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