Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage

BACKGROUND: The evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte structural and functional proteins, influencing responses to hemolytic stress during transfusion and disease. METHODS: We sought to identify such genetic varia...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Page, Grier P., Kanias, Tamir, Guo, Yuelong J., Lanteri, Marion C., Zhang, Xu, Mast, Alan E., Cable, Ritchard G., Spencer, Bryan R., Kiss, Joseph E., Fang, Fang, Endres-Dighe, Stacy M., Brambilla, Donald, Nouraie, Mehdi, Gordeuk, Victor R., Kleinman, Steve, Busch, Michael P., Gladwin, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245173/
https://ncbi.nlm.nih.gov/pubmed/34014839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146077
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