Order and disorder—An integrative structure of the full-length human growth hormone receptor

Because of its small size (70 kilodalton) and large content of structural disorder (>50%), the human growth hormone receptor (hGHR) falls between the cracks of conventional high-resolution structural biology methods. Here, we study the structure of the full-length hGHR in nanodiscs with small-ang...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Kassem, Noah, Araya-Secchi, Raul, Bugge, Katrine, Barclay, Abigail, Steinocher, Helena, Khondker, Adree, Wang, Yong, Lenard, Aneta J., Bürck, Jochen, Sahin, Cagla, Ulrich, Anne S., Landreh, Michael, Pedersen, Martin Cramer, Rheinstädter, Maikel C., Pedersen, Per Amstrup, Lindorff-Larsen, Kresten, Arleth, Lise, Kragelund, Birthe B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245047/
https://ncbi.nlm.nih.gov/pubmed/34193419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh3805
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