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Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin

Neural tube defects (NTDs) are the second most common structural birth defect. Senescence, a state of permanent cell cycle arrest, occurs only after neural tube closure. Maternal diabetes–induced NTDs are severe diabetic complications that lead to infant mortality or lifelong morbidity and may be li...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Xu, Cheng, Shen, Wei-Bin, Reece, E. Albert, Hasuwa, Hidetoshi, Harman, Christopher, Kaushal, Sunjay, Yang, Peixin
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245044/
https://ncbi.nlm.nih.gov/pubmed/34193422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf5089
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