A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1

Although pharmacological stimulation of TLRs has anti-tumor effects, it has not been determined whether endogenous stimulation of TLRs can lead to tumor rejection. Herein, we demonstrate the existence of an innate anti-glioma NK-mediated circuit initiated by glioma-released miR-1983 within exosomes,...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Shah, Diana, Comba, Andrea, Faisal, Syed M., Kadiyala, Padma, Baker, Gregory J., Alghamri, Mahmoud S., Doherty, Robert, Zamler, Daniel, Nuñez, Gabriel, Castro, Maria G., Lowenstein, Pedro R.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244780/
https://ncbi.nlm.nih.gov/pubmed/34249474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2021.1939601
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