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Drug repurposing in autosomal dominant polycystic kidney disease: back to the future with pioglitazone

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of end-stage kidney failure. At present, only one drug, tolvaptan, has been approved for use to slow disease progression, but its use is limited by reduced tolerability and idiosyncratic liver toxicity. Thiazolid...

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Détails bibliographiques
Publié dans:Clin Kidney J
Auteurs principaux: Mao, Zhiguo, Valluru, Manoj K, Ong, Albert C M
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8243263/
https://ncbi.nlm.nih.gov/pubmed/34221378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ckj/sfab062
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