Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

In response to DNA double-strand breaks (DSBs), repair proteins are recruited to the damaged sites. Ubiquitin signaling plays a critical role in coordinating protein recruitment during the DNA damage response. Here, we find that the microRNA biogenesis factor DGCR8 promotes tumor resistance to X-ray...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Hang, Qinglei, Zeng, Liyong, Wang, Li, Nie, Litong, Yao, Fan, Teng, Hongqi, Deng, Yalan, Yap, Shannon, Sun, Yutong, Frank, Steven J., Chen, Junjie, Ma, Li
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8242032/
https://ncbi.nlm.nih.gov/pubmed/34188037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24298-z
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