Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation

Duloxetine hydrochloride (DH) is a serotonin–norepinephrine reuptake inhibitor (SSNRI) indicated for the treatment of depression. Duloxetine suffers from reduced oral bioavailability (≈50%) due to hepatic metabolism. This study aims to develop DH buccoadhesive films to improve its bioavailability. D...

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Vydáno v:Drug Deliv
Hlavní autoři: El Sharawy, Amr Mostafa, Shukr, Marwa Hassan, Elshafeey, Ahmed Hassen
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8241170/
https://ncbi.nlm.nih.gov/pubmed/29172829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1402216
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