Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies

PURPOSE: Duloxetine (DLX) is dual serotonin and norepinephrine reuptake inhibitor suffering from limited bioavailability (≈ 40%) due to extensive hepatic metabolism. This work aims to formulate and evaluate DLX intranasal thermoreversible cubosomal gels to enhance its bioavailability and ensure effi...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Elsenosy, Fatma Mohamed, Abdelbary, Ghada Ahmed, Elshafeey, Ahmed Hassen, Elsayed, Ibrahim, Fares, Ahmed Roshdy
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732760/
https://ncbi.nlm.nih.gov/pubmed/33324051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S277352
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