Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity

BACKGROUND: The accumulation of the hepatotoxic substance protoporphyrin IX (PPIX) induced by aminolevulinate synthase 1 (ALAS1) activation is one of the important mechanisms of antituberculosis drug-induced hepatotoxicity (ATDH). Forkhead box protein O1 (FOXO1) may activate ALAS1 transcription. How...

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Bibliographic Details
Published in:Evid Based Complement Alternat Med
Main Authors: Zhang, Jingwei, Jiao, Lin, Song, Jiajia, Wu, Tao, Bai, Hao, Liu, Tangyuheng, Zhao, Zhenzhen, Hu, Xuejiao, Ying, Binwu
Format: Artigo
Language:Inglês
Published: Hindawi 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238576/
https://ncbi.nlm.nih.gov/pubmed/34249128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/3185874
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