Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury

BACKGROUND: Pregnane X receptor (PXR) regulates the expression of drug-metabolizing enzymes and transport enzymes. NF-κB not only plays a role in liver homeostasis and injury-healing processes by regulating inflammatory responses but may also regulate the transcription of PXR. Currently, genetic pol...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Jingwei, Zhao, Zhenzhen, Bai, Hao, Wang, Minjin, Jiao, Lin, Peng, Wu, Wu, Tao, Liu, Tangyuheng, Chen, Hao, Song, Xingbo, Wu, Lijuan, Hu, Xuejiao, Wu, Qian, Zhou, Juan, Song, Jiajia, Lyv, Mengyuan, Ying, Binwu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730870/
https://ncbi.nlm.nih.gov/pubmed/31490979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222033
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