An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module

Aberrant inflammation, such as that associated with inflammatory bowel disease (IBD), is fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module mediates controlled nuclear activation of RelA dimers from the latent cytoplasmic complexes. What provokes pathologica...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chawla, Meenakshi, Mukherjee, Tapas, Deka, Alvina, Chatterjee, Budhaditya, Sarkar, Uday Aditya, Singh, Amit K., Kedia, Saurabh, Lum, Josephine, Dhillon, Manprit Kaur, Banoth, Balaji, Biswas, Subhra K., Ahuja, Vineet, Basak, Soumen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237674/
https://ncbi.nlm.nih.gov/pubmed/34155144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024828118
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