Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland

Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary stem cell activation process as occurring upon target...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Vennekens, Annelies, Laporte, Emma, Hermans, Florian, Cox, Benoit, Modave, Elodie, Janiszewski, Adrian, Nys, Charlotte, Kobayashi, Hiroto, Malengier-Devlies, Bert, Chappell, Joel, Matthys, Patrick, Garcia, Marie-Isabelle, Pasque, Vincent, Lambrechts, Diether, Vankelecom, Hugo
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2021
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237615/
https://ncbi.nlm.nih.gov/pubmed/34161279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100052118
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