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Major depletion of SOX2(+) stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling
The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2(+) cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult Sox2(CreERT2/+);R26(iDTR/+) mice (after tamoxif...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5717068/ https://ncbi.nlm.nih.gov/pubmed/29208952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16796-2 |
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