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Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the mechanisms underlying the concurrent decline in bone mass, quality, and mechanosensitivity with age remain unclear. The important role of osteocytes in these processes and the age-related degeneration of...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8237574/ https://ncbi.nlm.nih.gov/pubmed/34161267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023999118 |
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