PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease

Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD) pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic Th17 cells, however remain unknown. Here, we uncover and characterize a distinct population of inflammatory hepatic CXCR3(+)...

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Publicado no:Cell Metab
Main Authors: Moreno-Fernandez, Maria E., Giles, Daniel A., Oates, Jarren R., Chan, Calvin C., Damen, Michelle S.M.A., Doll, Jessica R., Stankiewicz, Traci E., Chen, Xiaoting, Chetal, Kashish, Karns, Rebekah, Weirauch, Matthew, Romick-Rosendale, Lindsey, Xanthakos, Stavra A., Sheridan, Rachel, Szabo, Sara, Shah, Amy S., Helmrath, Michael A., Inge, Thomas H., Deshmukh, Hitesh, Salomonis, Nathan, Divanovic, Senad
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237408/
https://ncbi.nlm.nih.gov/pubmed/34004162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2021.04.018
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