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Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations
PURPOSE: To investigate the mechanism underlying the synergic interaction between Leber's hereditary optic neuropathy (LHON)-associated ND1 and mitochondrial tyrosyl-tRNA synthetase (YARS2) mutations. METHODS: Molecular dynamics simulation and differential scanning fluorimetry were used to eval...
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| Publicado en: | Invest Ophthalmol Vis Sci |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Association for Research in Vision and Ophthalmology
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8237128/ https://ncbi.nlm.nih.gov/pubmed/34156427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.7.22 |
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