The RNA-Binding Proteins SRP14 and HMGB3 Control HIV-1 Tat mRNA Processing and Translation During HIV-1 Latency

HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregulated in resting CD4(+) T-cells, the main reservoir of latent HIV in people with HIV (PWH) on antiretroviral therapy (ART). In this study, we examined the role of Tat RNA...

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Vydáno v:Front Genet
Hlavní autoři: Khoury, Georges, Lee, Michelle Y., Ramarathinam, Sri H., McMahon, James, Purcell, Anthony W., Sonza, Secondo, Lewin, Sharon R., Purcell, Damian F. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236859/
https://ncbi.nlm.nih.gov/pubmed/34194479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.680725
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