Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis

Esophageal squamous cell carcinoma (ESCC) is a recalcitrant cancer. The Chinese herbal monomer fangchinoline (FCL) has been reported to have anti-tumor activity in several human cancer cell types. However, the therapeutic efficacy and underlying mechanism on ESCC remain to be elucidated. In the pres...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Oncol
Päätekijät: Zhang, Yunjing, Wang, Shiwen, Chen, Yukun, Zhang, Junqian, Yang, Jing, Xian, Jingrong, Li, Lihui, Zhao, Hu, Hoffman, Robert M., Zhang, Yanmei, Jia, Lijun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2021
Aiheet:
Oncology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236818/
https://ncbi.nlm.nih.gov/pubmed/34195076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.666549
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