Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution

BACKGROUND: Evidence from in vitro and rodent studies suggests that leptin, a key signal of long-term energy reserves, promotes IGF1 synthesis and linear growth. This effect of leptin has not been fully investigated in humans. The aim of our study was to investigate the effect of leptin substitution...

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Dettagli Bibliografici
Pubblicato in:Int J Obes (Lond)
Autori principali: Beghini, Marianna, Brandt, Stephanie, Körber, Ingrid, Kohlsdorf, Katja, Vollbach, Heike, Lennerz, Belinda, Denzer, Christian, Shalitin, Shlomit, Santini, Ferruccio, Blum, Werner F., von Schnurbein, Julia, Wabitsch, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236407/
https://ncbi.nlm.nih.gov/pubmed/34002033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-021-00809-2
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