Downregulation of MicroRNA-495 Alleviates IL-1β Responses among Chondrocytes by Preventing SOX9 Reduction

PURPOSE: Our previous work demonstrated that miRNA-495 targets SOX9 to inhibit chondrogenesis of mesenchymal stem cells. In this study, we aimed to investigate whether miRNA-495-mediated SOX9 regulation could be a novel therapeutic target for osteoarthritis (OA) using an in vitro cell culture model....

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Veröffentlicht in:Yonsei Med J
Hauptverfasser: Joung, Soyeong, Yoon, Dong Suk, Cho, Sehee, Ko, Eun Ae, Lee, Kyoung-Mi, Park, Kwang Hwan, Lee, Jin Woo, Kim, Sung-Hwan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Yonsei University College of Medicine 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236342/
https://ncbi.nlm.nih.gov/pubmed/34164963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3349/ymj.2021.62.7.650
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