MALAT1 Regulated mTOR-Mediated Tau Hyperphosphorylation by Acting as a ceRNA of miR144 in Hippocampus Cells Exposed to High Glucose

AIM: High glucose (HG)-induced activation of mTOR promotes tau phosphorylation and leads to diabetes-associated dementia. This study aimed to explore the role of metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) in HG-induced neuronal cell injury. METHODS: Hippocampus cells were iso...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Interv Aging
Prif Awduron: Lu, Chong, Zhao, Yikui, Cao, Yan, Liu, Li, Wu, Shanshan, Li, Dongbin, Liu, Shuang, Xiao, Shuyuan, Wei, Yafen, Li, Xinyu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove 2021
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236260/
https://ncbi.nlm.nih.gov/pubmed/34188461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CIA.S304827
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