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Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62
Many proteins are transported into the endoplasmic reticulum by the universally conserved Sec61 channel. Post-translational transport requires two additional proteins, Sec62 and Sec63, but their functions are poorly defined. Here, we determined cryo-EM structures of several variants of Sec61–Sec62–S...
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| Vydáno v: | Nat Struct Mol Biol |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8236211/ https://ncbi.nlm.nih.gov/pubmed/33398175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00541-x |
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