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Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
Citrate plays a central role in cancer cells’ metabolism and regulation. Derived from mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate. The rapid turnover of these molecules in proliferative cancer cells maintains a...
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| Pubblicato in: | Int J Mol Sci |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8235534/ https://ncbi.nlm.nih.gov/pubmed/34205414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126587 |
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