Whole Exome Sequencing of 23 Multigeneration Idiopathic Scoliosis Families Reveals Enrichments in Cytoskeletal Variants, Suggests Highly Polygenic Disease

Adolescent idiopathic scoliosis (AIS) is a lateral spinal curvature >10° with rotation that affects 2–3% of healthy children across populations. AIS is known to have a significant genetic component, and despite a handful of risk loci identified in unrelated individuals by GWAS and next-generation...

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Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Terhune, Elizabeth A., Wethey, Cambria I., Cuevas, Melissa T., Monley, Anna M., Baschal, Erin E., Bland, Morgan R., Baschal, Robin, Trahan, G. Devon, Taylor, Matthew R. G., Jones, Kenneth L., Hadley Miller, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235452/
https://ncbi.nlm.nih.gov/pubmed/34208743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes12060922
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