Inhibition of Ceramide Synthesis Reduces α-Synuclein Proteinopathy in a Cellular Model of Parkinson’s Disease

Parkinson’s disease (PD) is a proteinopathy associated with the aggregation of α-synuclein and the formation of lipid–protein cellular inclusions, named Lewy bodies (LBs). LB formation results in impaired neurotransmitter release and uptake, which involve membrane traffic and require lipid synthesis...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Mingione, Alessandra, Pivari, Francesca, Plotegher, Nicoletta, Dei Cas, Michele, Zulueta, Aida, Bocci, Tommaso, Trinchera, Marco, Albi, Elisabetta, Maglione, Vittorio, Caretti, Anna, Bubacco, Luigi, Paroni, Rita, Bottai, Daniele, Ghidoni, Riccardo, Signorelli, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8234676/
https://ncbi.nlm.nih.gov/pubmed/34208778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126469
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