Co-Stimulatory versus Cell Death Aspects of Agonistic CD40 Monoclonal Antibody Selicrelumab in Chronic Lymphocytic Leukemia

SIMPLE SUMMARY: Previous observations have shown that CD40 activation of CLL cells via coculture with CD40L-expressing fibroblasts increases sensitivity to cell death by CD20 mAbs rituximab and obinutuzumab. We studied the activity of the fully human-agonistic CD40 mAb selicrelumab in primary CLL ce...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Delgado, Raquel, Kielbassa, Karoline, ter Burg, Johanna, Klein, Christian, Trumpfheller, Christine, de Heer, Koen, Kater, Arnon P., Eldering, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8234015/
https://ncbi.nlm.nih.gov/pubmed/34205588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13123084
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