The prognostic significance of Flap Endonuclease 1 (FEN1) in breast ductal carcinoma in situ

BACKGROUND: Impaired DNA repair mechanism is one of the cancer hallmarks. Flap Endonuclease 1 (FEN1) is essential for genomic integrity. FEN1 has key roles during base excision repair (BER) and replication. We hypothesised a role for FEN1 in breast cancer pathogenesis. This study aims to assess the...

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Bibliographic Details
Published in:Breast Cancer Res Treat
Main Authors: Al-Kawaz, Abdulbaqi, Miligy, Islam M., Toss, Michael S., Mohammed, Omar J., Green, Andrew R., Madhusudan, Srinivasan, Rakha, Emad A.
Format: Artigo
Language:Inglês
Published: Springer US 2021
Subjects:
Preclinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233293/
https://ncbi.nlm.nih.gov/pubmed/34117958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-021-06271-y
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