Potent efficacy of chlorpromazine in acute myeloid leukemia harboring KIT-D816V mutation

Acute myeloid leukemia (AML) is a heterogeneous disease often associated with poor prognosis. We previously showed that the localization of KIT-D816V at endolysosomes is critical to activate aberrant Akt signaling and Chlorpromazine (CPZ) perturbs the intracellular localization, leading to cell deat...

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Vydáno v:Leuk Res Rep
Hlavní autoři: Rai, Shinya, Tanaka, Hirokazu, Espinoza, J. Luis, Kumode, Takahiro, Matsumura, Itaru
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233227/
https://ncbi.nlm.nih.gov/pubmed/34194969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2021.100256
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