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Potent efficacy of chlorpromazine in acute myeloid leukemia harboring KIT-D816V mutation
Acute myeloid leukemia (AML) is a heterogeneous disease often associated with poor prognosis. We previously showed that the localization of KIT-D816V at endolysosomes is critical to activate aberrant Akt signaling and Chlorpromazine (CPZ) perturbs the intracellular localization, leading to cell deat...
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| Publicado no: | Leuk Res Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8233227/ https://ncbi.nlm.nih.gov/pubmed/34194969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lrr.2021.100256 |
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