Plasma Cell–Free DNA Profiling of PTEN-PI3K-AKT Pathway Aberrations in Metastatic Castration-Resistant Prostate Cancer

Tumor tissue from metastatic castration-resistant prostate cancer (mCRPC) harbors frequent copy number variations (CNVs) in the PTEN-PI3K-AKT pathway. However, identifying CNVs in plasma cell–free DNA (cfDNA) has proven to be challenging. With emerging data supporting Akt inhibition in PTEN-deficien...

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Bibliografske podrobnosti
izdano v:JCO Precis Oncol
Main Authors: Kwan, Edmond M., Dai, Chao, Fettke, Heidi, Hauser, Christine, Docanto, Maria M., Bukczynska, Patricia, Ng, Nicole, Foroughi, Siavash, Graham, Lisa-Jane K., Mahon, Kate, Tan, Winston, Wang, Xiaohong, Zhao, Zhixin, Zheng, Tiantian, Zhou, Kemin, Yu, Jianjun, Du, Pan, Horvath, Lisa G., Jia, Shidong, Kohli, Manish, Azad, Arun A.
Format: Artigo
Jezik:Inglês
Izdano: Wolters Kluwer Health 2021
Teme:
Original Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232889/
https://ncbi.nlm.nih.gov/pubmed/34250422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00424
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