Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors

The 3,5-dimethylisoxazole motif has become a useful and popular acetyl-lysine mimic employed in isoxazole-containing bromodomain and extra-terminal (BET) inhibitors but may introduce the potential for bioactivations into toxic reactive metabolites. As a test, we coupled deep neural models for quinon...

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Publicat a:Metabolites
Autors principals: Flynn, Noah R., Ward, Michael D., Schleiff, Mary A., Laurin, Corentine M. C., Farmer, Rohit, Conway, Stuart J., Boysen, Gunnar, Swamidass, S. Joshua, Miller, Grover P.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232216/
https://ncbi.nlm.nih.gov/pubmed/34203690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11060390
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