Tumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF

Discordant responses between brain metastases and extracranial tumors can arise from branched tumor evolution, underscoring the importance of profiling mutations to optimize therapy. However, the morbidity of brain biopsies limits their use. We investigated whether cell-free DNA (cfDNA) in CSF could...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Cheok, Stephanie Kim, Narayan, Azeet, Arnal-Estape, Anna, Gettinger, Scott, Goldberg, Sarah B., Kluger, Harriet M., Nguyen, Don, Patel, Abhijit, Chiang, Veronica
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2021
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232069/
https://ncbi.nlm.nih.gov/pubmed/34250381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00292
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